PROBLEMS ASSOCIATED WITH THE SAFETY ASSESSMENT OF FOOD CHEMICALS
Absolute safety cannot be proven
No protocol is adequate for all compounds
Extrapolation from high doses to low doses
Extrapolation from animals to man
Genetic variation
High cost
Additives may be safer than the food itself
EXTRAPOLATIONS
|
% IN DIET |
% ANIMALS W/CANCER |
|
1.0 |
10. |
|
0.1 |
1.0 |
|
0.01 |
0.1 |
|
0.001 |
0.01 |
|
0.0001 |
0.001 |