Toxicity Testing For Food Additives:

Look at FDA's Redbook 2000 for more details.

Concern Levels vs Exposure Graph

Acute Toxicity

Short-term Toxicity

Sub-chronic Toxicity

Metabolic and Pharmacokinetic Studies

Mutagenicity Tests

In vitro Carcinogenicity Tests

In vivo Carcinogenicity Tests

Reproductive Tests

Chronic Feeding Studies

Problems Associated with Testing for Safety

Important Considerations for toxicity Evaluations

Acceptable Dietary Risks for Carcinogens

Risk Assessment

Summary Table from Redbook II - Recommended test for risk levels