Recommended Toxicity Tests

 

  		     
 

Concern Levels

 I

II

III
Short-term Gene Toxicity

 

  		x

x

x
Metabolism and Pharmacokinetic Studies    

x

x
Short-term Toxicity with Rodents

 

  		x    
Subchronic Toxicity with Rodents    

x

x
Subchronic Toxicity with Rodents with non-rodents    

x

  
Reproduction Study with Teratology Phase    

x

x
One-year Toxicity Tests with Non-Rodents      

x
Carcinogenicity Study with Rodents      

x
Chronic Toxicity / Carcinogenicity with Rodents      

x

Source: Redbook II